Gene
hoxd12a
- ID
- ZDB-GENE-990415-118
- Name
- homeobox D12a
- Symbol
- hoxd12a Nomenclature History
- Previous Names
-
- hoxd-12
- hoxd12
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including fin; mesenchyme; pectoral fin bud; pectoral fin field; and tail bud. Human ortholog(s) of this gene implicated in clubfoot. Orthologous to human HOXD12 (homeobox D12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6901952 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hoxd12a | Zebrafish Nomenclature Committee | |
| MO1-hoxd12a | N/A | Sundaramoorthi et al., 2023 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|
|
UniProtKB:B0S5Y9
|
277 | ||||
|
UniProtKB:Q90471
|
262 |
1 - 2 of 2
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hoxd12a-201
(1)
|
Ensembl | 1,309 nt | ||
| mRNA |
hoxd12a-202
(1)
|
Ensembl | 1,396 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-78H1 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6901952 | Thisse et al., 2004 |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001126486 (1) | 1309 nt | ||
| Genomic | GenBank:BX322661 (1) | 146527 nt | ||
| Polypeptide | UniProtKB:B0S5Y9 (1) | 277 aa |
- Ishizaka, M., Maeno, A., Nakazawa, H., Fujii, R., Oikawa, S., Tani, T., Kanno, H., Koita, R., Kawamura, A. (2024) The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development. Scientific Reports. 14:2360223602
- Sundaramoorthi, H., Fallatah, W., Mary, J., Jagadeeswaran, P. (2023) Discovery of seven hox genes in zebrafish thrombopoiesis. Blood cells, molecules & diseases. 104:102796102796
- Matharu, N.K., Yadav, S., Kumar, M., Mishra, R.K. (2021) Role of vertebrate GAGA associated factor (vGAF) in early development of zebrafish. Cells & development. 166:203682
- Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., Graf, D., Crump, J.G. (2021) Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton. Development (Cambridge, England). 148(2):
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
- Pak, B., Schmitt, C.E., Choi, W., Kim, J.D., Han, O., Alsiö, J., Jung, D.W., Williams, D.R., Coppieters, W., Stainier, D.Y.R., Jin, S.W. (2020) Analyses of Avascular Mutants Reveal Unique Transcriptomic Signature of Non-conventional Endothelial Cells. Frontiers in cell and developmental biology. 8:589717
- Malmstrøm, M., Britz, R., Matschiner, M., Tørresen, O.K., Hadiaty, R.K., Yaakob, N., Tan, H.H., Jakobsen, K.S., Salzburger, W., Rüber, L. (2018) The Most Developmentally Truncated Fishes Show Extensive Hox Gene Loss and Miniaturized Genomes. Genome biology and evolution. 10:1088-1103
- Wang, J., Fei, F., Berberoglu, M.A., Sun, S., Wang, L., Dong, Z., Wang, X. (2018) Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis. Journal of molecular cell biology. 10(6):586-588
- Jimenez, L., Wang, J., Morrison, M.A., Whatcott, C., Soh, K.K., Warner, S., Bearss, D., Jette, C.A., Stewart, R.A. (2016) Phenotypic chemical screening using zebrafish neural crest reporters identifies retinoid acid as an inhibitor of epithelial morphogenesis. Disease models & mechanisms. 9(4):389-400
- Hayward, A.G., Joshi, P., Skromne, I. (2015) Spatiotemporal analysis of zebrafish hox gene regulation by Cdx4. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(12):1564-73
1 - 10 of 29
Show