Gene

hoxb8a

ID

ZDB-GENE-990415-108

Name

homeobox B8a

Symbol

hoxb8a Nomenclature History

Previous Names

gp-8
hoxb8
fj67g02
wu:fj67g02 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cell population proliferation and posterior lateral line neuromast primordium migration. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; neural tube; pancreatic system; paraxial mesoderm; and pronephros. Orthologous to human HOXB8 (homeobox B8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64159 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Breau et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hoxb8a Human Ortholog

No data available

Associated With hoxb8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR001827	Homeobox protein, antennapedia type, conserved site
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050948	Antp homeobox transcription factor
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Antp homeobox transcription factor	Helix-turn-helix motif	Homedomain-like superfamily	Homeobox, conserved site	Homeobox protein, antennapedia type, conserved site	Homeodomain	Homeodomain, metazoa
UniProtKB:Q8AWZ0 InterPro	245
UniProtKB:A0A8M2BJC8 InterPro	246

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	hoxb8a-201 (1) Ensembl	Ensembl		1,817 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000001809 (1)	Havana		1,752 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:Hox B8a

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations