Gene

hbaa1

ID

ZDB-GENE-980526-79

Name

hemoglobin, alpha adult 1

Symbol

hbaa1 Nomenclature History

Previous Names

AA1

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to hypoxia. Predicted to localize to haptoglobin-hemoglobin complex and hemoglobin complex. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Is expressed in eye; hematopoietic system; presumptive blood; and vasculature. Orthologous to several human genes including HBZ (hemoglobin subunit zeta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

33 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55446 (3 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hbaa1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
alpha thalassemia	Alliance	Thalassemias, alpha-	604131
familial erythrocytosis 7	Alliance	Erythrocytosis, familial, 7	617981
Heinz body anemia	Alliance	Heinz body anemias, alpha-	140700
hemoglobin H disease	Alliance	Hemoglobin H disease, nondeletional	613978
		Methemoglobinemia, alpha type	617973

Associated With hbaa1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000971	Globin
Family	IPR002338	Hemoglobin, alpha-type
Family	IPR002339	Hemoglobin, pi
Family	IPR050056	Hemoglobin and related oxygen transporters
Homologous_superfamily	IPR009050	Globin-like superfamily
Homologous_superfamily	IPR012292	Globin/Protoglobin

Domain Details Per Protein

Protein	Length	Globin	Globin-like superfamily	Globin/Protoglobin	Hemoglobin, alpha-type	Hemoglobin and related oxygen transporters	Hemoglobin, pi
UniProtKB:Q803Z5 InterPro	143
UniProtKB:Q90487 InterPro	143
UniProtKB:Q1JQ69 InterPro	143

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hbaa1-201 (1) Ensembl	Ensembl	651 nt	Select Tool
mRNA	ottdart00000002411 (1)	Havana	581 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000002413 (1)	Havana	581 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations