Gene
rarab
- ID
- ZDB-GENE-980526-72
- Name
- retinoic acid receptor, alpha b
- Symbol
- rarab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription by RNA polymerase II and pectoral fin development. Acts upstream of or within liver development; midbrain-hindbrain boundary development; and secondary heart field specification. Predicted to be located in nucleus. Is expressed in several structures, including endoderm; hindbrain neural keel; mesoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu883 (15 images)
- eu941 (15 images)
- l03399 (37 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute promyelocytic leukemia | Alliance | Leukemia, acute promyelocytic | 612376 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR047158 | Retinoic acid receptor, ligand-binding domain |
| Domain | IPR047159 | Retinoic acid receptor, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003078 | Retinoic acid receptor |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoic acid receptor | Retinoic acid receptor, DNA-binding domain | Retinoic acid receptor, ligand-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZTI3
|
458 | ||||||||
|
UniProtKB:E7EZ95
|
460 |
Interactions and Pathways
Plasmids
No data available