Gene

dlx2b

ID

ZDB-GENE-980526-18

Name

distal-less homeobox 2b

Symbol

dlx2b Nomenclature History

Previous Names

dlx5

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in several structures, including dental epithelium; dental mesenchyme; forebrain; parasphenoid; and splanchnocranium. Orthologous to human DLX2 (distal-less homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

50 figures from 30 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu649 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlx2b Human Ortholog

No data available

Associated With dlx2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Domain	IPR022135	Distal-less-like homeobox protein, N-terminal domain
Family	IPR050460	Distal-less homeobox transcription factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily