Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-166
Gene Name: sonic hedgehog a
Gene Symbol: shha
Previous Names: shh, syu, vhh1 (1), fc83d08, sonic you, sonic-you (1), vertebrate hedgehog homolog (1), wu:fc83d08 (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 333 figures from 250 publications
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  anal fin, anterior neural keel, anterior neural rod, axial chorda mesoderm (all 104) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 35 genotypes
Alleles: b240, shha_unspecified, t4, tbq70, tbx392 (all 6) expand
Knockdown reagents: MO1-shha (1), MO2-shha (1), MO3-shha (1), MO4-shha (1)
PHENOTYPE
Data: 24 figures from 15 publications
Observed in: adaxial cell, anatomical system, blood circulation, ceratobranchial 5 tooth (all 38) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Holoprosencephaly-3 142945
Microphthalmia with coloboma 5 611638
Schizencephaly 269160
Single median maxillary central incisor 147250
GENE ONTOLOGY
Ontology GO Term
Biological Process adenohypophysis development (more)
Cellular Component extracellular region (more)
Molecular Function hydrolase activity (more)
GO Terms (all 62)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR006141 (1)
  • InterPro:IPR009045 (1)
  • PROSITE:PS50817 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shha-001 (1) 2592
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM shha
    Tg(-2.4shha-A:GFP), Tg(-2.4shha-AB:GFP), Tg(-2.4shha-ABC:DsRed), Tg(-2.4shha-ABC:DsRed.T4), Tg(-2.4shha-ABC:GFP) (all 20) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shha Contained in: [BAC] CH211-105D1 (1) (order this), CH211-150E22 (1) (order this)
    shha Encodes: [EST] fc83d08
    [cDNA] MGC:194075 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131063 (1) 2592 bp
    Genomic GenBank:CU041319 (1) 174262 bp
    Select Tool
    Polypeptide UniProtKB:Q1MTB5 (1) 418 aa
    Sequence Clusters UniGene:36074 (1)
    Sequence Information (all 31)
    OTHER shha GENE PAGES
  • Gene:30269 (1)
  • VEGA:OTTDARG00000035495 (1)
  • Ensembl(Zv9):ENSDARG00000068567 (1)
  • MAPPING INFORMATION
    Chr: 7 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish shha 7  
    Human SHH 7 (7q36)
  • OMIM:600725
  • Gene:6469
  • Mouse Shh 5 ( 14.39 cM)
  • MGI:98297
  • Gene:20423
  • CITATIONS (610)