ZFIN ID: ZDB-GENE-980526-166
Gene Name: sonic hedgehog a
Gene Symbol: shha
Previous Names: shh, fc83d08, sonic you, sonic-you (1), syu, vertebrate hedgehog homolog (1), vhh1 (1), wu:fc83d08 (1)
Location: Chr: 7   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 393 figures from 298 publications
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Adult (90d-730d, breeding adult)
  anal fin, anterior neural keel, anterior neural keel ventral region, anterior neural rod (all 130) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 35 Genotypes
Knockdown reagents: MO1-shha (1), MO2-shha (1), MO3-shha (1), MO4-shha (1)

Allele Type Mutagen Suppliers
shha_unspecified Unspecified
t4 Deficiency SPONTANEOUS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • tbq70 Unknown ENU
    tbx392 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tq252 Point Mutation
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 27 figures from 17 publications
    Observed in: adaxial cell, anatomical system, blood circulation, ceratobranchial 5 tooth (all 48) expand
    DISEASE ASSOCIATED WITH shha HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    holoprosencephaly Holoprosencephaly-3 142945
    Microphthalmia with coloboma 5 611638
    Schizencephaly 269160
    Single median maxillary central incisor 147250
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 66)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000320 (1)
  • InterPro:IPR001657 (1)
  • InterPro:IPR001767 (1)
  • InterPro:IPR003586 (1)
  • InterPro:IPR003587 (1)
  • InterPro:IPR006141 (1)
  • InterPro:IPR009045 (1)
  • InterPro:IPR028992 (1)
  • PROSITE:PS50817 (1)
  • Pfam:PF01079 (1)
  • Pfam:PF01085 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA shha-001 (1) 2592
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM shha
    Tg(-2.4shha-A:GFP), Tg(-2.4shha-AB:GFP), Tg(-2.4shha-ABC:DsRed), Tg(-2.4shha-ABC:DsRed.T4), Tg(-2.4shha-ABC:GFP) (all 23) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    shha Contained in: [BAC] CH211-105D1 (1) (order this), CH211-150E22 (1) (order this)
    shha Encodes: [EST] fc83d08
    [cDNA] MGC:194075 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131063 (1) 2602 bp
    Genomic GenBank:CU041319 (1) 174262 bp
    Select Tool
    Polypeptide UniProtKB:A0A0B5JF88 (1) 418 aa
    Sequence Clusters UniGene:115833 (1)
    Sequence Information (all 35)
    OTHER shha GENE PAGES
  • Gene:30269 (1)
  • VEGA:OTTDARG00000035495 (1)
  • Ensembl(Zv9):ENSDARG00000068567 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish shha 7  
    Human SHH 7 (7q36)
  • OMIM:600725
  • Gene:6469
  • Mouse Shh 5 ( 14.39 cM)
  • MGI:98297
  • Gene:20423
  • Orthology Details
    CITATIONS (666)