ZFIN ID: ZDB-GENE-980526-142
Gene Name: Janus kinase 1
Gene Symbol: jak1
Previous Names: etID309794.6 (1), fb93e10, jak1 kinase, wu:fb93e10
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:55268]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  artery, axial vasculature, cranial ganglion, somite (all 7) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
t22598 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-jak1 (1), MO2-jak1 (1)
    PHENOTYPE
    Data: 2 figures from Iwanami et al., 2011
    Observed in: pro-T cell, T cell differentiation, thymus
    DISEASE ASSOCIATED WITH jak1 HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process T cell differentiation in thymus (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000299 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR016251 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR019748 (1)
  • InterPro:IPR019749 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR020776 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50057 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA jak1-001 (1) 6613
    ncRNA jak1-002 (1) 724
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM jak1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    jak1Contained in: [BAC] CH211-201N5 (1) (order this), DKEY-202I2 (1) (order this)
    jak1Encodes: [EST] fb93e10
    [cDNA] MGC:55268 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131073 (1) 3854bp
    Genomic GenBank:AL954175 (1) 176268bp
    Select Tool
    Polypeptide UniProtKB:C0SPC5 (1) 1153aa
    Sequence Clusters UniGene:74470 (1)
    Sequence Information (all 21)
    OTHER jak1 GENE PAGES
  • Gene:30280 (1)
  • VEGA:OTTDARG00000019779 (1)
  • Ensembl(GRCz10):ENSDARG00000020625 (1)
  • ORTHOLOGY for jak1 (Chr: 6)
    Species Symbol Chromosome Accession # Evidence
    Human JAK1 1
  • Gene:3716
  • OMIM:147795
  • HGNC:6190
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Jak1 4
  • MGI:96628
  • Gene:16451
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (35)