Gene

jak1

ID
ZDB-GENE-980526-142
Name
Janus kinase 1
Symbol
jak1 Nomenclature History
Previous Names
  • etID309794.6 (1)
  • fb93e10
  • jak1 kinase
  • wu:fb93e10
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; metal ion binding activity; and non-membrane spanning protein tyrosine kinase activity. Involved in T cell differentiation in thymus. Predicted to localize to cytoskeleton; endomembrane system; and membrane. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; colorectal cancer; hepatocellular carcinoma; ovarian cancer; and pancreatic adenocarcinoma. Is expressed in cranial ganglion; otic vesicle; somite; and vasculature. Orthologous to human JAK1 (Janus kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Iwanami et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jak1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Autoinflammation, immune dysregulation, and eosinophilia 618999
Associated With jak1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041046 JAK, FERM F2 lobe domain
Domain IPR041155 FERM F1 lobe ubiquitin-like domain
Domain IPR041381 JAK1-3/TYK2, pleckstrin homology-like domain
Family IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Family IPR020776 Tyrosine-protein kinase, non-receptor Jak1
Family IPR051286 Janus Kinase (JAK)
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Band 4.1 domain FERM central domain FERM domain FERM F1 lobe ubiquitin-like domain FERM superfamily, second domain JAK1-3/TYK2, pleckstrin homology-like domain JAK, FERM F2 lobe domain Janus Kinase (JAK) Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, non-receptor Jak1 Tyrosine-protein kinase, non-receptor Jak/Tyk2
UniProtKB:Q7ZU16
InterPro
1153
UniProtKB:O12990
InterPro
1153
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA jak1-201 (1)
Ensembl
Ensembl 6,613 nt
ncRNA jak1-002 (1)
Ensembl
Ensembl 724 nt
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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