ZFIN ID: ZDB-GENE-980526-142
Gene Name: Janus kinase 1
Gene Symbol: jak1

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Previous Names: etID309794.6 (1), fb93e10, jak1 kinase, wu:fb93e10

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:55268]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  artery, axial vasculature, cranial ganglion, somite (all 7) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
t22598 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-jak1 (1), MO2-jak1 (1)
    PHENOTYPE
    Data: 2 figures from Iwanami et al., 2011
    Observed in: pro-T cell, T cell differentiation, thymus
    DISEASE ASSOCIATED WITH jak1 HUMAN ORTHOLOGNo data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process T cell differentiation in thymus (more)
    Cellular Component cytoskeleton (more)
    Molecular Function ATP binding (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000299 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR016251 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR019748 (1)
  • InterPro:IPR019749 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR020776 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50057 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA jak1-001 (1) 6613
    ncRNA jak1-002 (1) 724
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM jak1
    Tg(ubb:LOXP-BFP-LOXP-jak1_L910P-FLAG,cryaa:Cerulean), Tg(ubb:LOXP-BFP-LOXP-jak1_S703I-FLAG,cryaa:Cerulean)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    jak1Contained in: [BAC] CH211-201N5 (1) (order this), DKEY-202I2 (1) (order this)
    jak1Encodes: [EST] fb93e10
    [cDNA] MGC:55268 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131073 (1) 3854bp
    Genomic GenBank:AL954175 (1) 176268bp
    Select Tool
    Polypeptide UniProtKB:C0SPC5 (1) 1153aa
    Sequence Clusters UniGene:74470 (1)
    Sequence Information (all 21)
    OTHER jak1 GENE PAGES
  • Gene:30280 (1)
  • VEGA:OTTDARG00000019779 (1)
  • Ensembl(GRCz10):ENSDARG00000020625 (1)
  • ORTHOLOGY for jak1 (Chr: 6)
    Species Symbol Chromosome Accession # Evidence
    Human JAK1 1
  • Gene:3716
  • OMIM:147795
  • HGNC:6190
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Jak1 4
  • MGI:96628
  • Gene:16451
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (35)