Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-142
Gene Name: Janus kinase 1
Gene Symbol: jak1
Previous Names: etID309794.6 (1), fb93e10, jak1 kinase, wu:fb93e10
Location: Chr: 6   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:55268]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  artery, axial vasculature, cranial ganglion, somite (all 7) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 2 genotypes
Alleles: t22598
Knockdown reagents: MO1-jak1 (1), MO2-jak1 (1)
PHENOTYPE
Data: 2 figures from Iwanami et al., 2011
Observed in: pro-T cell, T cell differentiation, thymus
GENE ONTOLOGY
Ontology GO Term
Biological Process T cell differentiation in thymus (more)
Cellular Component cytoskeleton (more)
Molecular Function ATP binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000299 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR000980 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR016251 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR019748 (1)
  • InterPro:IPR019749 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR020776 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50057 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.2 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA jak1-001 (1) 6613
    ncRNA jak1-002 (1) 724
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM jak1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    jak1 Contained in: [BAC] CH211-201N5 (1) (order this), DKEY-202I2 (1)
    jak1 Encodes: [EST] fb93e10
    [cDNA] MGC:55268 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131073 (1) 3854 bp
    Genomic GenBank:AL954175 (1) 176268 bp
    Select Tool
    Polypeptide UniProtKB:C0SPC5 (1) 1153 aa
    Sequence Clusters UniGene:74470 (1)
    Sequence Information (all 21)
    OTHER jak1 GENE PAGES
  • Gene:30280 (1)
  • VEGA:OTTDARG00000019779 (1)
  • Ensembl(Zv9):ENSDARG00000020625 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish jak1 6  
    Human JAK1 1 (1p32.3-p31.3)
  • OMIM:147795
  • Gene:3716
  • Mouse Jak1 4 ( 46.19 cM)
  • MGI:96628
  • Gene:16451
  • Orthology Details
    CITATIONS (29)