ZFIN ID: ZDB-GENE-980526-114
Gene Name: deltaB
Gene Symbol: dlb
Previous Names: deltab, etID309872.5 (1), sc:d0400
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 46 figures from 26 publications
Directly Submitted Expression Data: 6 figures (13 images) from Thisse et al., 2005 [eu57]
  7 figures (25 images) from Thisse et al., 2008 [cssl:d400]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
  adenohypophyseal placode, basal plate midbrain region, brain, caudal tuberculum (all 38) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: la015666Tg, la025026Tg, sa16279, sa16283, sa16415 (all 6) expand
Knockdown reagents: MO1-dlb (1), MO2-dlb (1), MO3-dlb (1)
PHENOTYPE
Data: Fig. 2 from Mizoguchi et al., 2011
Observed in: posterior lateral line ganglion neuron

Phenotype of Human Orthologue OMIM Phenotype ID
Spondylocostal dysostosis 1, autosomal recessive 277300
GENE ONTOLOGY
Ontology GO Term
Biological Process diencephalon development (more)
Cellular Component integral component of membrane (more)
Molecular Function calcium ion binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001774 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011651 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51051 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF01414 (1)
  • Pfam:PF07657 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlb-001 (1) 3030
    ncRNA dlb-002 (1) 441
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlb Contained in: [BAC] CH211-222C22 (1) (order this)
    dlb Contains: [SNP] rs3727879 (1)
    dlb Encodes: [EST] eu57 (1)
    [cDNA] cssl:d400 (1) (order this), MGC:100773 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130958 (1) 3007 bp
    Genomic GenBank:BX005407 (1) 209796 bp Blast at MegaBLAST
    Polypeptide UniProtKB:O57409 (1) 615 aa
    Sequence Clusters UniGene:574 (1)
    Sequence Information (all 16)
    OTHER dlb GENE PAGES
  • Gene:30141 (1)
  • VEGA:OTTDARG00000018419 (1)
  • Ensembl(Zv9):ENSDARG00000004232 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dlb 5  
    Human DLL3 19 (19q13)
  • OMIM:602768
  • Gene:10683
  • Orthology Details
    CITATIONS (74)