Gene
npr2
- ID
- ZDB-GENE-141030-2
- Name
- natriuretic peptide receptor 2
- Symbol
- npr2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; guanylate cyclase activity; and protein kinase activity. Involved in cardiac muscle cell proliferation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Is expressed in several structures, including fin; head; kidney; neural tube; and oocyte. Orthologous to human NPR2 (natriuretic peptide receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acromesomelic dysplasia, Maroteaux type | Alliance | Acromesomelic dysplasia 1, Maroteaux type | 602875 |
| Miura type epiphyseal chondrodysplasia | Alliance | Epiphyseal chondrodysplasia, Miura type | 615923 |
| Short stature with nonspecific skeletal abnormalities | 616255 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001828 | Receptor, ligand binding region |
| Family | IPR001170 | Adenylyl cyclase class-4/guanylyl cyclase |
| Family | IPR050401 | Cyclic nucleotide synthase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
| Homologous_superfamily | IPR029787 | Nucleotide cyclase |
Domain Details Per Protein
| Protein | Length | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Cyclic nucleotide synthase | Nucleotide cyclase | Periplasmic binding protein-like I | Protein kinase domain | Protein kinase-like domain superfamily | Receptor, ligand binding region | Serine-threonine/tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KGK2
|
1043 | ||||||||||
|
UniProtKB:A0A8M3B2U7
|
1048 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available