Gene

znf318

ID

ZDB-GENE-140106-251

Name

zinc finger protein 318

Symbol

znf318 Nomenclature History

Previous Names

zmp:0000001291 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Predicted to be active in nucleoplasm. Orthologous to human ZNF318 (zinc finger protein 318).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa16667	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa16778	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa28052	Allele with one point mutation	Unknown	Premature Stop	ENU
sa35406	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With znf318 Human Ortholog

No data available

Associated With znf318 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger
Domain	IPR013087	Zinc finger C2H2-type

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Domain Details Per Protein

Protein	Length	Matrin/U1-C-like, C2H2-type zinc finger	Zinc finger C2H2-type
UniProtKB:A0A8M1RKK4 InterPro	2230

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 13

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
aberrant processed transcript	znf318-202 (1) Ensembl	Ensembl		669 nt	Select Tool ZFIN BLAST
mRNA	znf318-201 (1) Ensembl	Ensembl		7,641 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEYP-121D4	CU571336	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_068212997 (1)	7555 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU571336 (1)	135731 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M1RKK4 (1)	2230 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	ZNF318	6	Ensembl:ENSG00000171467 Gene:24149 OMIM:617512 HGNC:13578	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Zfp318	17	Ensembl:ENSMUSG00000015597 MGI:1889348 Gene:57908	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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