Gene

znf365

ID

ZDB-GENE-131121-260

Name

zinc finger protein 365

Symbol

znf365 Nomenclature History

Previous Names

si:dkey-84k15.6

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Enables lipid antigen binding activity and lipopolysaccharide binding activity. Acts upstream of or within defense response to Gram-negative bacterium. Is expressed in several structures, including blastoderm cell; digestive system; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in uric acid nephrolithiasis. Orthologous to human ZNF365 (zinc finger protein 365).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa39174	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Citations
MO1-znf365	N/A	Du et al., 2017

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Human Disease

Associated With znf365 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
uric acid nephrolithiasis	Alliance	{Nephrolithiasis, uric acid, susceptibility to}	605990

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Associated With znf365 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR052283	Genomic Stability and Neuronal Morphogenesis Regulator

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Domain Details Per Protein

Protein	Additional Resources	Length	Genomic Stability and Neuronal Morphogenesis Regulator
UniProtKB:E7FDA3	InterPro	345

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 17

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	znf365-201 (1) Ensembl	Ensembl	1,730 nt	Select Tool ZFIN BLAST
mRNA	znf365-202 (1) Ensembl	Ensembl	1,050 nt	Select Tool ZFIN BLAST
mRNA	znf365-203 (1) Ensembl	Ensembl	1,172 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-znf365	polyclonal	znf365		Rabbit	IHC WB		1

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Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-84K15	BX927349	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_068214631 (1)	1170 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX927349 (1)	159649 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7FDA3 (1)	345 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	ZNF365	10	Ensembl:ENSG00000285551 Gene:22891 HGNC:18194 OMIM:607818	Conserved genome location (synteny) (2) Amino acid sequence comparison (2) Phylogenetic tree (1)
Mouse	Zfp365	10	Ensembl:ENSMUSG00000037855 Gene:216049 MGI:2143676	Conserved genome location (synteny) (2) Phylogenetic tree (1) Amino acid sequence comparison (2)

Citations

Include unpublished citations

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