Gene
wnk4b
- ID
- ZDB-GENE-131120-119
- Name
- WNK lysine deficient protein kinase 4b
- Symbol
- wnk4b Nomenclature History
- Previous Names
-
- wnk4l (1)
- si:dkeyp-61g11.1
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of metal ion transport; and renal sodium ion absorption. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Pseudohypoaldosteronism, type IIB | 614491 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR024678 | Serine/threonine-protein kinase OSR1/WNK, CCT domain |
| Family | IPR050588 | With No Lysine (K) Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase OSR1/WNK, CCT domain | With No Lysine (K) Ser/Thr Protein Kinase |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QPF3
|
1550 |
Interactions and Pathways
No data available
Plasmids
No data available