Gene
brinp3a.2
- ID
- ZDB-GENE-131119-53
- Name
- bone morphogenetic protein/retinoic acid inducible neural-specific 3a, tandem duplicate 2
- Symbol
- brinp3a.2 Nomenclature History
- Previous Names
-
- brinp3b (1)
- si:ch211-205j18.2
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Predicted to act upstream of or within positive regulation of neuron differentiation and regulation of cell cycle. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Is expressed in several structures, including fin; fin bud; gill; head; and muscle. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human BRINP3 (BMP/retinoic acid inducible neural specific 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Giousoh et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa17402 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20744 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40730 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40731 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | BMP/retinoic acid-inducible neural-specific protein | Membrane attack complex component/perforin (MACPF) domain |
|---|---|---|---|
|
UniProtKB:F1R441
|
754 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
brinp3a.2-201
(1)
|
Ensembl | 6,603 nt | ||
| mRNA |
brinp3a.2-202
(1)
|
Ensembl | 2,409 nt | ||
| ncRNA |
brinp3a.2-002
(1)
|
Ensembl | 818 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-205J18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001309829 (1) | 2650 nt | ||
| Genomic | GenBank:BX537110 (2) | 166351 nt | ||
| Polypeptide | UniProtKB:F1R441 (1) | 754 aa |
- Comparative Orthology
- Alliance
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Giousoh, A., Vaz, R., Bryson-Richardson, R.J., Whisstock, J.C., Verkade, H., Bird, P.I. (2015) Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Gene expression patterns : GEP. 18(1-2):37-43
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