Gene
itchb
- ID
- ZDB-GENE-131024-2
- Name
- itchy E3 ubiquitin protein ligase b
- Symbol
- itchb Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have ubiquitin protein ligase activity. Involved in posterior lateral line neuromast primordium migration. Predicted to localize to cytoplasm. Is expressed in posterior lateral line primordium. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Angers et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Autoimmune disease, multisystem, with facial dysmorphism | 613385 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000569 | HECT domain |
| Domain | IPR001202 | WW domain |
| Family | IPR024928 | E3 ubiquitin-protein ligase, SMURF1 type |
| Family | IPR050409 | E3 ubiquitin-protein ligase |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035983 | HECT, E3 ligase catalytic domain |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | E3 ubiquitin-protein ligase | E3 ubiquitin-protein ligase, SMURF1 type | HECT domain | HECT, E3 ligase catalytic domain | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:U6C7R6
|
867 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available