Gene

cita

ID

ZDB-GENE-130530-981

Name

citron rho-interacting serine/threonine kinase a

Symbol

cita Nomenclature History

Previous Names

cit
zmp:0000000978 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 17. Orthologous to human CIT (citron rho-interacting serine/threonine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cita Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 17	Alliance	Microcephaly 17, primary, autosomal recessive	617090

Associated With cita Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR001180	Citron homology (CNH) domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Family	IPR050839	Rho-associated Serine/Threonine Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	AGC-kinase, C-terminal	C1-like domain superfamily	Citron homology (CNH) domain	PH-like domain superfamily	Pleckstrin homology domain	Protein kinase, ATP binding site	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Protein kinase domain	Protein kinase-like domain superfamily	Rho-associated Serine/Threonine Kinase	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain
UniProtKB:E7FGD8 InterPro	1989
UniProtKB:A0A8M9QF24 InterPro	2344
UniProtKB:A0A8M9PZB2 InterPro	2358
UniProtKB:A0A8M9Q5W0 InterPro	2350
UniProtKB:A0A8M9QA07 InterPro	2336

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cita-201 (1) Ensembl	Ensembl		7,035 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations