Gene
slx1b
- ID
- ZDB-GENE-130530-826
- Name
- SLX1 homolog B, structure-specific endonuclease subunit
- Symbol
- slx1b Nomenclature History
- Previous Names
-
- zmp:0000000823 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable 5'-flap endonuclease activity and crossover junction DNA endonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to act upstream of or within DNA recombination and DNA repair. Predicted to be located in nucleus. Predicted to be part of Slx1-Slx4 complex. Orthologous to human SLX1B (SLX1 homolog B, structure-specific endonuclease subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
kh66 | Allele with one deletion | Unknown | Frameshift | CRISPR | |
kh67 | Allele with one delins | Unknown | Frameshift | CRISPR | |
sa14819 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa27082 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa41067 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000305 | GIY-YIG endonuclease |
Domain | IPR048749 | Structure-specific endonuclease subunit SLX1, C-terminal domain |
Family | IPR027520 | Structure-specific endonuclease subunit Slx1 |
Family | IPR050381 | SLX1 structure-specific endonuclease |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR035901 | GIY-YIG endonuclease superfamily |
Domain Details Per Protein
Protein | Additional Resources | Length | GIY-YIG endonuclease | GIY-YIG endonuclease superfamily | SLX1 structure-specific endonuclease | Structure-specific endonuclease subunit Slx1 | Structure-specific endonuclease subunit SLX1, C-terminal domain | Zinc finger, RING/FYVE/PHD-type |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IAZ1 | InterPro | 260 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-234L14 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001327857 (1) | 1223 nt | ||
Genomic | GenBank:BX957253 (2) | 197310 nt | ||
Polypeptide | UniProtKB:A0A0R4IAZ1 (1) | 260 aa |
- Shin, U., Nakhro, K., Oh, C.K., Carrington, B., Song, H., Varshney, G.K., Kim, Y., Song, H., Jeon, S., Robbins, G., Kim, S., Yoon, S., Choi, Y.J., Kim, Y.J., Burgess, S., Kang, S., Sood, R., Lee, Y., Myung, K. (2021) Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. DNA repair. 107:103173
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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