Gene
pik3ca
- ID
- ZDB-GENE-130409-1
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
- Symbol
- pik3ca Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have 1-phosphatidylinositol-3-kinase activity; ATP binding activity; and phosphatidylinositol bisphosphate kinase activity. Involved in regulation of collateral sprouting in absence of injury. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); colorectal cancer (multiple); and cutaneous Paget's disease. Is expressed in eye. Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schmidt et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
breast cancer | Alliance | Breast cancer, somatic | 114480 |
CLOVES syndrome | Alliance | CLOVE syndrome, somatic | 612918 |
colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Cowden syndrome 5 | Alliance | Cowden syndrome 5 | 615108 |
epidermal nevus | Alliance | Nevus, epidermal, somatic | 162900 |
hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
lung cancer | Alliance | Nonsmall cell lung cancer, somatic | 211980 |
ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
seborrheic keratosis | Alliance | Keratosis, seborrheic, somatic | 182000 |
stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
Cerebral cavernous malformations 4, somatic | 619538 | ||
CLAPO syndrome, somatic | 613089 | ||
Hemifacial myohyperplasia, somatic | 606773 | ||
Macrodactyly, somatic | 155500 | ||
Megalencephaly-capillary malformation-polymicrogyria syndrome, somatic | 602501 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
Domain | IPR003113 | Phosphatidylinositol 3-kinase, adaptor-binding domain |
Family | IPR015433 | Phosphatidylinositol kinase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR016024 | Armadillo-type fold |
Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Homologous_superfamily | IPR035892 | C2 domain superfamily |
Homologous_superfamily | IPR036940 | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily |
Homologous_superfamily | IPR042236 | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily |
Domain Details Per Protein
Protein | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F1QAD7
|
1069 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
pik3ca-201
(1)
|
Ensembl | 3684 nt | |
mRNA |
pik3ca-202
(1)
|
Havana | 4279 nt | |
mRNA |
pik3ca-203
(1)
|
Ensembl | 3989 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance