Gene

afg3l1

ID

ZDB-GENE-121214-51

Name

AFG3-like AAA ATPase 1

Symbol

afg3l1 Nomenclature History

Previous Names

si:ch1073-174d20.2

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of m-AAA complex.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With afg3l1 Human Ortholog

No data available

Associated With afg3l1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR000642	Peptidase M41
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR011546	Peptidase M41, FtsH extracellular
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR005936	ATP-dependent zinc metalloprotease, FtsH
Family	IPR050928	ATP-dependent Zinc Metalloprotease
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR037219	Peptidase M41-like

Domain Details Per Protein

Protein	Length	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	ATP-dependent Zinc Metalloprotease	ATP-dependent zinc metalloprotease, FtsH	Peptidase M41	Peptidase M41, FtsH extracellular	Peptidase M41-like	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7F6D6 InterPro	751

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:ch1073-174d20.2-201 (1) Ensembl	Ensembl		3,979 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations