Gene

kcnh1b

ID

ZDB-GENE-121128-4

Name

potassium voltage-gated channel, subfamily H (eag-related), member 1b

Symbol

kcnh1b Nomenclature History

Previous Names

zmp:0000000565 (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Exhibits voltage-gated potassium channel activity. Involved in hindbrain formation and somitogenesis. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Is expressed in gill; nervous system; pleuroperitoneal region; and trunk. Orthologous to human KCNH1 (potassium voltage-gated channel subfamily H member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Stengel et al., 2012

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Stengel et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kcnh1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Temple-Baraitser syndrome	611816
		Zimmermann-Laband syndrome 1	135500

Associated With kcnh1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000014	PAS domain
Domain	IPR000595	Cyclic nucleotide-binding domain
Domain	IPR000700	PAS-associated, C-terminal
Domain	IPR005821	Ion transport domain
Family	IPR003949	Potassium channel, voltage-dependent, EAG
Homologous_superfamily	IPR014710	RmlC-like jelly roll fold
Homologous_superfamily	IPR018490	Cyclic nucleotide-binding domain superfamily
Homologous_superfamily	IPR035965	PAS domain superfamily
Repeat	IPR001610	PAC motif

Domain Details Per Protein

Protein	Length	Cyclic nucleotide-binding domain	Cyclic nucleotide-binding domain superfamily	Ion transport domain	PAC motif	PAS-associated, C-terminal	PAS domain	PAS domain superfamily	Potassium channel, voltage-dependent, EAG	RmlC-like jelly roll fold
UniProtKB:A0A8M3AXZ2 InterPro	965
UniProtKB:K4EHU2 InterPro	956

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations