Gene
c5
- ID
- ZDB-GENE-120510-2
- Name
- complement component 5
- Symbol
- c5 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have endopeptidase inhibitor activity. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including asthma; complement component 5 deficiency; liver cirrhosis; neutropenia; and paroxysmal nocturnal hemoglobinuria. Orthologous to human C5 (complement C5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complement component 5 deficiency | Alliance | C5 deficiency | 609536 |
| [Eculizumab, poor response to] | 615749 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR001134 | Netrin domain |
| Domain | IPR001599 | Alpha-2-macroglobulin |
| Domain | IPR002890 | Macroglobulin domain |
| Domain | IPR009048 | Alpha-macroglobulin, receptor-binding |
| Domain | IPR011625 | Alpha-2-macroglobulin, bait region domain |
| Domain | IPR011626 | Alpha-macroglobulin-like, TED domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR040839 | Macroglobulin domain MG4 |
| Domain | IPR041425 | Complement C3/4/5, macroglobulin domain MG1 |
| Domain | IPR041555 | Macroglobulin domain MG3 |
| Domain | IPR048843 | Complement component 5, CUB domain |
| Family | IPR050473 | Alpha-2-macroglobulin/Complement system |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR018081 | Anaphylatoxin, complement system |
| Homologous_superfamily | IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Complement C3/4/5, macroglobulin domain MG1 | Complement component 5, CUB domain | Immunoglobulin-like fold | Macroglobulin domain | Macroglobulin domain MG3 | Macroglobulin domain MG4 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FCV2
|
1704 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available