Gene
trpc4b
- ID
- ZDB-GENE-120329-1
- Name
- transient receptor potential cation channel, subfamily C, member 4b
- Symbol
- trpc4b Nomenclature History
- Previous Names
-
- trpc4
- trpc4a (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables monoatomic cation channel activity. Acts upstream of or within monoatomic cation transport. Located in plasma membrane. Is expressed in integument; olfactory bulb; and olfactory placode. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa22689 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32051 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42591 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42592 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013555 | Transient receptor ion channel domain |
| Family | IPR002153 | Transient receptor potential channel, canonical |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR002110 | Ankyrin repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical |
|---|---|---|---|---|---|---|---|
| UniProtKB:U3N7D8 | InterPro PDB | 915 | |||||
| UniProtKB:A0A0R4IM91 | InterPro | 915 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trpc4b-201
(1)
|
Ensembl | 3,938 nt | ||
| mRNA |
trpc4b-202
(1)
|
Ensembl | 2,782 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-74I1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001289881 (1) | 2782 nt | ||
| Genomic | GenBank:CR855389 (1) | 182027 nt | ||
| Polypeptide | UniProtKB:A0A0R4IM91 (1) | 915 aa |
- Vinayagam, D., Quentin, D., Yu-Strzelczyk, J., Sitsel, O., Merino, F., Stabrin, M., Hofnagel, O., Yu, M., Ledeboer, M.W., Nagel, G., Malojcic, G., Raunser, S. (2020) Structural basis of TRPC4 regulation by calmodulin and pharmacological agents. eLIFE. 9:
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073
- Vinayagam, D., Mager, T., Apelbaum, A., Bothe, A., Merino, F., Hofnagel, O., Gatsogiannis, C., Raunser, S. (2018) Electron cryo-microscopy structure of the canonical TRPC4 ion channel. eLIFE. 7
- Gao, S., Liu, S., Yao, J., Li, N., Yuan, Z., Zhou, T., Li, Q., Liu, Z. (2017) Genomic organization and evolution of olfactory receptors and trace amine-associated receptors in channel catfish, Ictalurus punctatus. Biochimica et biophysica acta. 1861(3):644-651
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- von Niederhäusern, V., Kastenhuber, E., Stäuble, A., Gesemann, M., and Neuhauss, S.C. (2013) Phylogeny and expression of canonical transient receptor potential (TRPC) genes in developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(12):1427-41
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