Gene
dlg5b.1
- ID
- ZDB-GENE-120206-4
- Name
- discs, large homolog 5b (Drosophila), tandem duplicate 1
- Symbol
- dlg5b.1 Nomenclature History
- Previous Names
-
- dlg5b.3
- dlg5b
- zmp:0000000771 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to be involved in negative regulation of hippo signaling. Predicted to act upstream of or within regulation of apoptotic process. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5).
- Genome Resources
- Note
-
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Yuksel-Vogel-Bauser syndrome | 620703 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CARD domain | Death-like domain superfamily | Disks large homolog 5, N-terminal | Disks large homologue 5, SH3 domain | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | MAGUK Family Regulators of Signaling Pathways | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QF19
|
1907 | ||||||||||||
|
UniProtKB:A0A8M3BEE2
|
1881 | ||||||||||||
|
UniProtKB:A0A8M9QN58
|
1830 | ||||||||||||
|
UniProtKB:A0A8M9QJE1
|
1804 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dlg5b.1-201
(1)
|
Ensembl | 6,650 nt | ||
| mRNA |
dlg5b.1-202
(1)
|
Ensembl | 1,900 nt | ||
| mRNA |
dlg5b.1-203
(1)
|
Ensembl | 6,081 nt | ||
| mRNA |
dlg5b.1-204
(1)
|
Ensembl | 6,159 nt | ||
| mRNA |
dlg5b.1-205
(1)
|
Ensembl | 5,360 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-2177F3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480449 (1) | 6285 nt | ||
| Genomic | GenBank:FO704672 (1) | 41221 nt | ||
| Polypeptide | UniProtKB:A0A8M9QF19 (2) | 1907 aa |
- Silic, M.R., Black, M.M., Zhang, G. (2021) Phylogenetic and developmental analyses indicate complex functions of Calcium-Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(10):1477-1493
- Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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