Gene
lpar4
- ID
- ZDB-GENE-120201-1
- Name
- lysophosphatidic acid receptor 4
- Symbol
- lpar4 Nomenclature History
- Previous Names
-
- si:rp71-37a9.4
- zmp:0000000975
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits lysophosphatidic acid receptor activity. Involved in angiogenesis. Predicted to localize to integral component of plasma membrane. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa12936 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-lpar4 | N/A | Yukiura et al., 2011 |
MO2-lpar4 | N/A | Yukiura et al., 2011 |
TALEN1-lpar4 | Okasato et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
---|---|---|---|
UniProtKB:A0A0N4STT7
|
351 | ||
UniProtKB:A0A8M9PN34
|
351 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-92I17 | ZFIN Curated Data | |
Contained in | BAC | RP71-37A9 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_001334677 (1) | |||
Genomic | GenBank:CU302318 (1) | 211023 nt | ||
Polypeptide | UniProtKB:A0A0N4STT7 (1) | 351 aa |
- Comparative Orthology
- Alliance
- Okasato, R., Kano, K., Kise, R., Inoue, A., Fukuhara, S., Aoki, J. (2021) An ATX-LPA6-Gα13-ROCK axis shapes and maintains caudal vein plexus in zebrafish. iScience. 24:103254
- Wang, J., Chen, Y., Zeng, Z., Feng, R., Wang, Q., Zhang, Q., Sun, K., Chen, A.F., Lu, Y., Yu, Y. (2021) HMGA2 contributes to vascular development and sprouting angiogenesis by promoting IGFBP2 production. Experimental cell research. 408(1):112831
- Yukiura, H., Hama, K., Nakanaga, K., Tanaka, M., Asaoka, Y., Okudaira, S., Arima, N., Inoue, A., Hashimoto, T., Arai, H., Kawahara, A., Nishina, H., and Aoki, J. (2011) Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. The Journal of biological chemistry. 286(51):43972-83
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