Gene
prf1.8
- ID
- ZDB-GENE-111212-12
- Name
- perforin 1.8
- Symbol
- prf1.8 Nomenclature History
- Previous Names
-
- si:ch211-282e16.5
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and pore-forming activity. Predicted to act upstream of or within immune response; killing of cells of another organism; and leukocyte mediated cytotoxicity. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; familial hemophagocytic lymphohistiocytosis 2; human immunodeficiency virus infectious disease; multiple sclerosis; and non-Langerhans-cell histiocytosis. Orthologous to human PRF1 (perforin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020863 | Membrane attack complex component/perforin domain, conserved site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR020864 | Membrane attack complex component/perforin (MACPF) domain |
| Domain | IPR037300 | Perforin-1, C2 domain |
| Family | IPR001862 | Membrane attack complex component/perforin/complement C9 |
| Family | IPR052784 | Perforin-1 pore-forming |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Membrane attack complex component/perforin/complement C9 | Membrane attack complex component/perforin domain, conserved site | Membrane attack complex component/perforin (MACPF) domain | Perforin-1, C2 domain | Perforin-1 pore-forming |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:I3ITP0
|
574 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bx547993.2-201
(1)
|
Ensembl | 1,908 nt |
Interactions and Pathways
No data available
Plasmids
No data available