Gene
mars2
- ID
- ZDB-GENE-111201-1
- Name
- methionyl-tRNA synthetase 2, mitochondrial
- Symbol
- mars2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable methionine-tRNA ligase activity. Predicted to be involved in methionyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 25 and spastic ataxia 3. Orthologous to human MARS2 (methionyl-tRNA synthetase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined oxidative phosphorylation deficiency 25 | Alliance | ?Combined oxidative phosphorylation deficiency 25 | 616430 |
| spastic ataxia 3 | Alliance | Spastic ataxia 3, autosomal recessive | 611390 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR015413 | Methionyl/Leucyl tRNA synthetase |
| Domain | IPR033911 | Methioninyl-tRNA synthetase core domain |
| Domain | IPR041872 | Methionyl-tRNA synthetase, anticodon-binding domain |
| Family | IPR014758 | Methionyl-tRNA synthetase |
| Family | IPR023457 | Methionine-tRNA synthetase, type 2 |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
Domain Details Per Protein
| Protein | Additional Resources | Length | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Methionine-tRNA synthetase, type 2 | Methioninyl-tRNA synthetase core domain | Methionyl/Leucyl tRNA synthetase | Methionyl-tRNA synthetase | Methionyl-tRNA synthetase, anticodon-binding domain | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F5M3 | InterPro | 595 |
Interactions and Pathways
No data available
Plasmids
No data available