Gene

ambra1a

ID

ZDB-GENE-111104-2

Name

autophagy/beclin-1 regulator 1a

Symbol

ambra1a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Involved in chordate embryonic development; locomotory behavior; and skeletal muscle fiber development. Is expressed in several structures, including blastodisc; oral cavity; otic vesicle; pleuroperitoneal region; and tail bud. Orthologous to human AMBRA1 (autophagy and beclin 1 regulator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ambra1a Human Ortholog

No data available

Associated With ambra1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Family	IPR052596	Activating Molecule in BECN1-Regulated Autophagy
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Activating Molecule in BECN1-Regulated Autophagy	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:E7FAG6 InterPro	1315
UniProtKB:A0A8M1RIC3 InterPro	1344

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ambra1a-201 (1) Ensembl	Ensembl	6,776 nt	Select Tool
mRNA	ambra1a-202 (1) Ensembl	Ensembl	3,220 nt	Select Tool
ncRNA	ambra1a-203 (1) Ensembl	Ensembl	3,870 nt	Select Tool
ncRNA	ambra1a-204 (1) Ensembl	Ensembl	2,842 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations