Gene

flvcr2a

ID

ZDB-GENE-111020-14

Name

FLVCR choline and putative heme transporter 2a

Symbol

flvcr2a Nomenclature History

Previous Names

flvcr2

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable ethanolamine transmembrane transporter activity; heme binding activity; and heme transmembrane transporter activity. Predicted to be involved in heme export and transport across blood-brain barrier. Predicted to act upstream of or within transmembrane transport. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Orthologous to human FLVCR2 (FLVCR choline and putative heme transporter 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With flvcr2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome	Alliance	Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome	225790

Associated With flvcr2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR020846	Major facilitator superfamily domain
Family	IPR011701	Major facilitator superfamily
Family	IPR049680	Choline/ethanolamine transporter FLVCR1-2/SLC49-like
Homologous_superfamily	IPR036259	MFS transporter superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Choline/ethanolamine transporter FLVCR1-2/SLC49-like	Major facilitator superfamily	Major facilitator superfamily domain	MFS transporter superfamily
UniProtKB:A0A0R4ILB2	InterPro	470

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	flvcr2a-201 (1) Ensembl	Ensembl		1,293 nt	Select Tool ZFIN BLAST
mRNA	flvcr2a-202 (1) Ensembl	Ensembl		1,413 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations