Gene
duox2
- ID
- ZDB-GENE-111007-1
- Name
- dual oxidase 2
- Symbol
- duox2 Nomenclature History
- Previous Names
-
- duoxa (1)
- zmp:0000001198
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Acts upstream of or within thyroid gland development. Is expressed in brain; intestine; thyroid follicle; thyroid primordium; and ultimobranchial body. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 5. Orthologous to human DUOXA1 (dual oxidase maturation factor 1) and DUOXA2 (dual oxidase maturation factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-duox2 | (2) | |
| CRISPR2-duox2 | Trubiroha et al., 2018 | |
| CRISPR3-duox2 | Salis et al., 2021 |
1 - 3 of 3
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thyroid dyshormonogenesis 5 | Alliance | Thyroid dyshormonogenesis 5 | 274900 |
1 - 1 of 1
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M1RI64 | InterPro | 329 |
1 - 1 of 1
- Genome Browsers
- No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
duoxa1-201
(1)
|
Ensembl | 2,201 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance