Gene
kif5ab
- ID
- ZDB-GENE-110510-3
- Name
- kinesin family member 5A, b
- Symbol
- kif5ab Nomenclature History
- Previous Names
-
- si:ch73-130n22.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex; axon guidance; and synaptic vesicle transport. Predicted to localize to kinesin complex and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; hereditary spastic paraplegia 10; multiple sclerosis; prostate cancer; and rheumatoid arthritis. Is expressed in nervous system. Orthologous to human KIF5A (kinesin family member 5A).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from Campbell et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa7055 | Allele with one point mutation | Unknown | Cryptic Donor Splice Site, Premature Stop | ENU | |
sa9911 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa16963 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa17684 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
amyotrophic lateral sclerosis type 25 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to, 25} | 617921 |
hereditary spastic paraplegia 10 | Alliance | Spastic paraplegia 10, autosomal dominant | 604187 |
Myoclonus, intractable, neonatal | 617235 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
Domain | IPR001752 | Kinesin motor domain |
Family | IPR027640 | Kinesin-like protein |
Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
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Domain Details Per Protein
Protein | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|
UniProtKB:A0A8M1PSD5
|
1023 | |||||
UniProtKB:A0A8M3ATT8
|
1050 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
kif5ab-201
(1)
|
Ensembl | 3,262 nt | ||
mRNA |
kif5ab-202
(1)
|
Ensembl | 972 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-130N22 | ||
Contained in | BAC | CH211-125M22 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009302769 (1) | 6048 nt | ||
Genomic | GenBank:BX950854 (1) | 171896 nt | ||
Polypeptide | UniProtKB:A0A8M3ATT8 (1) | 1050 aa |
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Campbell, P.D., Shen, K., Sapio, M.R., Glenn, T.D., Talbot, W.S., Marlow, F.L. (2014) Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:14717-32
- Campbell, P.D., and Marlow, F.L. (2013) Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development. Gene expression patterns : GEP. 13(7):271-279
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