Gene

inpp5b

ID

ZDB-GENE-110411-228

Name

inositol polyphosphate-5-phosphatase B

Symbol

inpp5b Nomenclature History

Previous Names

si:ch211-175f12.3 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have inositol-1,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including Kupffer's vesicle development; melanosome transport; and pronephric duct morphogenesis. Predicted to localize to cytosol and membrane. Orthologous to human INPP5B (inositol polyphosphate-5-phosphatase B).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Luo et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With inpp5b Human Ortholog

No data available

Associated With inpp5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR000300	Inositol polyphosphate-related phosphatase
Domain	IPR031896	INPP5B, PH domain
Domain	IPR037793	OCRL1/INPP5B, INPP5c domain
Domain	IPR047078	Inositol polyphosphate 5-phosphatase OCRL, RhoGAP
Domain	IPR048869	OCRL-1/2, ASH domain
Family	IPR046985	Inositol 5-phosphatase
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036691	Endonuclease/exonuclease/phosphatase superfamily

Domain Details Per Protein

Protein	Length	Endonuclease/exonuclease/phosphatase superfamily	Immunoglobulin-like fold	Inositol 5-phosphatase	Inositol polyphosphate 5-phosphatase OCRL, RhoGAP	Inositol polyphosphate-related phosphatase	INPP5B, PH domain	OCRL-1/2, ASH domain	OCRL1/INPP5B, INPP5c domain	Rho GTPase-activating protein domain	Rho GTPase activation protein
UniProtKB:A0A8M6YTK6 InterPro	744
UniProtKB:A0A8M6YVC4 InterPro	573
UniProtKB:A0A8M3AQB1 InterPro	907
UniProtKB:A0A8M6Z189 InterPro	803

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	inpp5b-202 (1) Ensembl	Ensembl	871 nt	Select Tool
mRNA	inpp5b-203 (1) Ensembl	Ensembl	3,427 nt	Select Tool ZFIN BLAST
ncRNA	inpp5b-002 (1) Ensembl	Ensembl	869 nt	Select Tool
ncRNA	inpp5b-003 (1) Ensembl	Ensembl	350 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations