Gene

tnk2b

ID

ZDB-GENE-110411-165

Name

tyrosine kinase, non-receptor, 2b

Symbol

tnk2b Nomenclature History

Previous Names

ackb (1)
si:ch73-329g8.1

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including peptidyl-tyrosine autophosphorylation; regulation of cell population proliferation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human TNK2 (tyrosine kinase non receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnk2b Human Ortholog

No data available

Associated With tnk2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001452	SH3 domain
Domain	IPR015116	Cdc42 binding domain-like
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR021619	Mig-6 domain
Domain	IPR030220	Activated CDC42 kinase 1, UBA domain
Domain	IPR049587	TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain
Family	IPR052112	EGFR Signaling Regulator Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR037085	Cdc42 binding domain-like superfamily

Domain Details Per Protein

Protein	Length	Activated CDC42 kinase 1, UBA domain	Cdc42 binding domain-like	Cdc42 binding domain-like superfamily	EGFR Signaling Regulator Kinase	Mig-6 domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	SH3 domain	SH3-like domain superfamily	TNK(ACK)-like non-receptor tyrosine-protein kinases, SAM domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain
UniProtKB:A0A0R4IH27 InterPro	1078
UniProtKB:A0A8M9QJL9 InterPro	1024
UniProtKB:A0A8M9PXR5 InterPro	1118
UniProtKB:A0A8M9QFB3 InterPro	1115
UniProtKB:A0A8M9QNC5 InterPro	1092
UniProtKB:A0A8M2BAU8 InterPro	1093

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tnk2b-201 (1) Ensembl	Ensembl	902 nt	Select Tool
mRNA	tnk2b-202 (1) Ensembl	Ensembl	5,146 nt	Select Tool ZFIN BLAST
mRNA	tnk2b-203 (1) Ensembl	Ensembl	331 nt	Select Tool
ncRNA	tnk2b-002 (1) Ensembl	Ensembl	536 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations