Gene
tecta
- ID
- ZDB-GENE-110411-120
- Name
- tectorin alpha
- Symbol
- tecta Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have extracellular matrix structural constituent. Involved in otolith tethering. Predicted to localize to collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 12; autosomal recessive nonsyndromic deafness 21; and sensorineural hearing loss. Is expressed in inner ear and otic vesicle. Orthologous to human TECTA (tectorin alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant nonsyndromic deafness 12 | Alliance | Deafness, autosomal dominant 8/12 | 601543 |
autosomal recessive nonsyndromic deafness 21 | Alliance | Deafness, autosomal recessive 21 | 603629 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000742 | EGF-like domain |
Domain | IPR001007 | VWFC domain |
Domain | IPR001507 | Zona pellucida domain |
Domain | IPR001846 | von Willebrand factor, type D domain |
Domain | IPR002919 | Trypsin Inhibitor-like, cysteine rich domain |
Domain | IPR003886 | NIDO domain |
Domain | IPR014853 | VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
Domain | IPR025615 | TILa domain |
Family | IPR052749 | Alpha-tectorin |
Homologous_superfamily | IPR036084 | Serine protease inhibitor-like superfamily |
Homologous_superfamily | IPR042235 | Zona pellucida, ZP-C domain |
Domain Details Per Protein
Protein | Length | Alpha-tectorin | EGF-like domain | NIDO domain | Serine protease inhibitor-like superfamily | TILa domain | Trypsin Inhibitor-like, cysteine rich domain | von Willebrand factor, type D domain | VWFC domain | VWF/SSPO/Zonadhesin-like, cysteine-rich domain | Zona pellucida domain | Zona pellucida, ZP-C domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M6YZF6
|
1803 | |||||||||||
UniProtKB:A0A8M3ASW3
|
2201 |
Interactions and Pathways
No data available
Plasmids
No data available