Gene
kl
- ID
- ZDB-GENE-110221-1
- Name
- klotho
- Symbol
- kl Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have beta-glucosidase activity. Predicted to be involved in aging; carbohydrate metabolic process; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to extracellular space and integral component of membrane. Human ortholog(s) of this gene implicated in Prinzmetal angina; coronary artery disease; intracranial embolism; and spondylosis. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and yolk syncytial layer. Orthologous to human KL (klotho).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Tumoral calcinosis, hyperphosphatemic, familial, 3 | 617994 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glycoside hydrolase family 1 | Glycoside hydrolase superfamily |
|---|---|---|---|
|
UniProtKB:F1RC43
|
990 | ||
|
UniProtKB:A0A8N7TDV5
|
990 |
Interactions and Pathways
No data available
Plasmids
No data available