Gene
p2ry12
- ID
- ZDB-GENE-110208-4
- Name
- purinergic receptor P2Y12
- Symbol
- p2ry12 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled purinergic nucleotide receptor activity. Involved in microglial cell activation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| platelet-type bleeding disorder 8 | Alliance | Bleeding disorder, platelet-type, 8 | 609821 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | P2Y12 purinoceptor |
|---|---|---|---|---|
|
UniProtKB:E7F2G6
|
345 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
p2ry12-201
(1)
|
Ensembl | 1,308 nt | ||
| mRNA |
p2ry12-202
(1)
|
Ensembl | 1,371 nt |
Interactions and Pathways
No data available
Plasmids
No data available