Gene
rspo4
- ID
- ZDB-GENE-110103-2
- Name
- R-spondin 4
- Symbol
- rspo4 Nomenclature History
- Previous Names
-
- si:dkey-107i16.4
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 4. Orthologous to human RSPO4 (R-spondin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonsyndromic congenital nail disorder 4 | Alliance | Anonychia congenita | 206800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR043601 | R-spondin, Fu-CRD domain |
| Family | IPR051514 | R-spondin domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
| Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | R-spondin domain-containing protein | R-spondin, Fu-CRD domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:M5AN99
|
241 |
Interactions and Pathways
No data available
Plasmids
No data available