Gene

myh11b

ID

ZDB-GENE-101124-2

Name

myosin, heavy chain 11b, smooth muscle

Symbol

myh11b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to be involved in regulation of microtubule motor activity. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in patent ductus arteriosus and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myh11b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
thoracic aortic aneurysm	Alliance	Aortic aneurysm, familial thoracic 4	132900
		Megacystis-microcolon-intestinal hypoperistalsis syndrome 2	619351
		Visceral myopathy 2	619350

Associated With myh11b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002928	Myosin tail
Domain	IPR004009	Myosin, N-terminal, SH3-like
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Kinesin motor domain superfamily	Myosin, N-terminal, SH3-like	Myosin S1 fragment, N-terminal	Myosin tail	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M6Z539 InterPro	2005

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myh11b-201 (1) Ensembl	Ensembl	6,302 nt	Select Tool
mRNA	myh11b-202 (1) Ensembl	Ensembl	642 nt	Select Tool ZFIN BLAST
mRNA	myh11b-203 (1) Ensembl	Ensembl	261 nt	Select Tool ZFIN BLAST
mRNA	myh11b-204 (1) Ensembl	Ensembl	678 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations