Gene

plch2b

ID

ZDB-GENE-101112-1

Name

phospholipase C, eta 2b

Symbol

plch2b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity and phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within intracellular signal transduction and lipid metabolic process. Orthologous to human PLCH2 (phospholipase C eta 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa8455	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14770	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa16949	Allele with one point mutation	Unknown	Premature Stop	ENU
sa31834	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa35094	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With plch2b Human Ortholog

No data available

Associated With plch2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

No data available

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 11

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	plch2b-201 (1) Ensembl	Ensembl		4,553 nt	Select Tool ZFIN BLAST
mRNA	plch2b-202 (1) Ensembl	Ensembl		2,340 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-183J2	CR933820	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_068218657 (1)	6450 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR933820 (1)	230267 nt	Select Tool MegaBLAST
Polypeptide	RefSeq:XP_068074758 (1)		Select Tool ZFIN BLAST NCBI BLAST UCSC BLAT Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

Species	Symbol	Chromosome	Accession #	Evidence
Human	PLCH2	1	Ensembl:ENSG00000149527 Ensembl:ENSG00000276429 Gene:9651 OMIM:612836 HGNC:29037	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Plch2	4	Ensembl:ENSMUSG00000029055 MGI:2443078 Gene:269615	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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