Gene
ptpn9a
- ID
- ZDB-GENE-101027-1
- Name
- protein tyrosine phosphatase non-receptor type 9a
- Symbol
- ptpn9a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within erythrocyte maturation and primitive hemopoiesis. Is expressed in blastomere; brain; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Bu et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
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Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | CRAL/TRIO, N-terminal domain | CRAL/TRIO, N-terminal domain superfamily | Protein-Tyrosine Phosphatase | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F716
|
571 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptpn9a-201
(1)
|
Ensembl | 2,701 nt | ||
| mRNA |
ptpn9a-202
(1)
|
Ensembl | 2,393 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-239G12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005162973 (1) | 2654 nt | ||
| Genomic | GenBank:CR354425 (1) | 161571 nt | ||
| Polypeptide | UniProtKB:E7F716 (1) | 571 aa |
- Watt, A.T., Head, B., Leonard, S.W., Tanguay, R.L., Traber, M.G. (2021) Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio). The Journal of Nutritional Biochemistry. 97:108801
- Wu, W., Hale, A.J., Lemeer, S., den Hertog, J. (2017) Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Scientific Reports. 7:8460
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Bu, Y., Su, F., Wang, X., Gao, H., Lei, L., Chang, N., Wu, Q., Hu, K., Zhu, X., Chang, Z., Meng, K., Xiong, J.W. (2014) Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. Journal of Cell Science. 127(Pt 12):2761-70
- Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53
- van Eekelen, M., Overvoorde, J., van Rooijen, C., and den Hertog, J. (2010) Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One. 5(9):e12573
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