Gene
lrrk1
- ID
- ZDB-GENE-101019-2
- Name
- leucine-rich repeat kinase 1
- Symbol
- lrrk1 Nomenclature History
- Previous Names
-
- zmp:0000000961
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase activity and purine ribonucleoside triphosphate binding activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteosclerotic metaphyseal dysplasia | Alliance | Osteosclerotic metaphyseal dysplasia | 615198 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR020859 | Roc domain |
| Domain | IPR032171 | C-terminal of Roc (COR) domain |
| Family | IPR050216 | Leucine-rich repeat domain-containing protein |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036770 | Ankyrin repeat-containing domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR002110 | Ankyrin repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
| Repeat | IPR025875 | Leucine rich repeat 4 |
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | C-terminal of Roc (COR) domain | Leucine-rich repeat | Leucine rich repeat 4 | Leucine-rich repeat domain-containing protein | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | P-loop containing nucleoside triphosphate hydrolase | Protein kinase-like domain superfamily | Roc domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | WD40-repeat-containing domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QDD6
|
2007 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance