Gene

arhgef6

ID

ZDB-GENE-101013-2

Name

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Symbol

arhgef6 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in lamellipodium assembly. Predicted to be active in cytoplasm and lamellipodium. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Tay et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef6 Human Ortholog

No data available

Associated With arhgef6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR001715	Calponin homology domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR032409	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain
Domain	IPR046376	RhoGEF 6/7, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036872	CH domain superfamily

Domain Details Per Protein

Protein	Length	Calponin homology domain	CH domain superfamily	Dbl homology (DH) domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	RhoGEF 6/7, PH domain	Rho guanine nucleotide exchange factor 6/7, coiled-coil domain	SH3 domain	SH3-like domain superfamily
UniProtKB:E7F836 InterPro	766
UniProtKB:A0A8M2BKJ3 InterPro	795

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef6-201 (1) Ensembl	Ensembl	3,333 nt	Select Tool ZFIN BLAST
mRNA	arhgef6-202 (1) Ensembl	Ensembl	5,872 nt	Select Tool ZFIN BLAST
mRNA	arhgef6-203 (1) Ensembl	Ensembl	295 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations