Gene
kcnj14
- ID
- ZDB-GENE-100922-48
- Name
- potassium inwardly rectifying channel subfamily J member 14
- Symbol
- kcnj14 Nomenclature History
- Previous Names
-
- Kir2.4 (1)
- si:ch211-120k19.4
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables inward rectifier potassium channel activity. Acts upstream of or within camera-type eye development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in atrium and cardiac ventricle. Orthologous to human KCNJ14 (potassium inwardly rectifying channel subfamily J member 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chiang et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa36083 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR040445 | Potassium channel, inwardly rectifying, transmembrane domain |
Domain | IPR041647 | Inward rectifier potassium channel, C-terminal |
Family | IPR016449 | Potassium channel, inwardly rectifying, Kir |
Homologous_superfamily | IPR013518 | Potassium channel, inwardly rectifying, Kir, cytoplasmic |
Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
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Domain Details Per Protein
Protein | Length | Immunoglobulin E-set | Inward rectifier potassium channel, C-terminal | Potassium channel, inwardly rectifying, Kir | Potassium channel, inwardly rectifying, Kir, cytoplasmic | Potassium channel, inwardly rectifying, transmembrane domain |
---|---|---|---|---|---|---|
UniProtKB:F1R7M8
|
542 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
kcnj14-201
(1)
|
Ensembl | 2,837 nt | ||
mRNA |
kcnj14-202
(1)
|
Ensembl | 4,104 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-120K19 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001326474 (1) | |||
Genomic | GenBank:AL929505 (1) | 178839 nt | ||
Polypeptide | UniProtKB:F1R7M8 (1) | 542 aa |
- Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021) Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(4):687-713
- Chiang, C.Y., Ching, Y.H., Chang, T.Y., Hu, L.S., Yong, Y.S., Keak, P.Y., Mustika, I., Lin, M.D., Liao, B.Y. (2019) Novel eye genes systematically discovered through an integrated analysis of mouse transcriptomes and phenome. Computational and structural biotechnology journal. 18:73-82
- Hassinen, M., Korajoki, H., Abramochkin, D., Krivosheya, P., Vornanen, M. (2019) Transcript expression of inward rectifier potassium channels of Kir2 subfamily in Arctic marine and freshwater fish species. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 189(6):735-749
- Hassinen, M., Haverinen, J., Hardy, M.E., Shiels, H.A., Vornanen, M. (2015) Inward rectifier potassium current (I K1) and Kir2 composition of the zebrafish (Danio rerio) heart. Pflugers Archiv : European journal of physiology. 467(12):2437-46
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