Gene
arhgef37
- ID
- ZDB-GENE-100514-3
- Name
- Rho guanine nucleotide exchange factor (GEF) 37
- Symbol
- arhgef37 Nomenclature History
- Previous Names
-
- arhgef37l
- gef969 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. Is expressed in blastoderm and shield. Orthologous to human ARHGEF37 (Rho guanine nucleotide exchange factor 37).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Junker et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hu3278 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18496 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22474 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45516 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR004148 | BAR domain |
| Family | IPR051492 | Dynamin-binding and Rho GEF |
| Homologous_superfamily | IPR027267 | AH/BAR domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | BAR domain | Dbl homology (DH) domain superfamily | Dbl homology domain | Dynamin-binding and Rho GEF | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F3M3 | InterPro | 709 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef37-201
(1)
|
Ensembl | 3,340 nt | ||
| mRNA |
arhgef37-202
(1)
|
Ensembl | 2,284 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-282E7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068213336 (1) | 3079 nt | ||
| Genomic | GenBank:BX537152 (1) | 243729 nt | ||
| Polypeptide | UniProtKB:E7F3M3 (1) | 709 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75
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