Gene
snap91a
- ID
- ZDB-GENE-100422-6
- Name
- synaptosome associated protein 91a
- Symbol
- snap91a Nomenclature History
- Previous Names
-
- snap91
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and vesicle budding from membrane. Predicted to act upstream of or within clathrin coat assembly. Predicted to be active in clathrin-coated pit; clathrin-coated vesicle; and synaptic vesicle. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Orthologous to human SNAP91 (synaptosome associated protein 91).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a337 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| la019721Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-snap91a | Thyme et al., 2019 | |
| CRISPR2-snap91a | Thyme et al., 2019 | |
| CRISPR3-snap91a | Thyme et al., 2019 | |
| CRISPR4-snap91a | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | ANTH domain superfamily | AP180 N-terminal homology (ANTH) domain | Clathrin coat assembly protein AP180-like | ENTH domain | ENTH/VHS |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B4T0 | InterPro | 898 | |||||
| UniProtKB:A0A8M9PUY1 | InterPro | 920 | |||||
| UniProtKB:A0A8M2B586 | InterPro | 925 | |||||
| UniProtKB:A0A8M3ATM5 | InterPro | 632 | |||||
| UniProtKB:A0A8N7T6A8 | InterPro | 923 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
snap91-201
(1)
|
Ensembl | 4,249 nt | ||
| mRNA |
snap91a-202
(1)
|
Ensembl | 2,742 nt | ||
| mRNA |
snap91a-203
(1)
|
Ensembl | 2,709 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-66C10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-83G2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021473013 (1) | 3545 nt | ||
| Genomic | GenBank:AL844887 (1) | 243870 nt | ||
| Polypeptide | UniProtKB:A0A8M2B586 (1) | 925 aa |
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Gallagher, T.L., Tietz, K.T., Morrow, Z.T., McCammon, J.M., Goldrich, M.L., Derr, N.L., Amacher, S.L. (2017) Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation. Developmental Biology. 429(1):225-239
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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