Gene
tymp
- ID
- ZDB-GENE-100415-1
- Name
- thymidine phosphorylase
- Symbol
- tymp Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 1,4-alpha-oligoglucan phosphorylase activity and thymidine phosphorylase activity. Predicted to be involved in pyrimidine nucleoside metabolic process. Predicted to act upstream of or within pyrimidine nucleobase metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| mitochondrial DNA depletion syndrome 1 | Alliance | Mitochondrial DNA depletion syndrome 1 (MNGIE type) | 603041 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017872 | Pyrimidine-nucleoside phosphorylase, conserved site |
| Domain | IPR000312 | Glycosyl transferase, family 3 |
| Domain | IPR013102 | Pyrimidine nucleoside phosphorylase, C-terminal |
| Domain | IPR017459 | Glycosyl transferase family 3, N-terminal domain |
| Family | IPR000053 | Thymidine/pyrimidine-nucleoside phosphorylase |
| Family | IPR018090 | Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic |
| Homologous_superfamily | IPR035902 | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily |
| Homologous_superfamily | IPR036320 | Glycosyl transferase family 3, N-terminal domain superfamily |
| Homologous_superfamily | IPR036566 | Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyl transferase, family 3 | Glycosyl transferase family 3, N-terminal domain | Glycosyl transferase family 3, N-terminal domain superfamily | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain superfamily | Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic | Pyrimidine-nucleoside phosphorylase, conserved site | Pyrimidine nucleoside phosphorylase, C-terminal | Pyrimidine nucleoside phosphorylase-like, C-terminal domain superfamily | Thymidine/pyrimidine-nucleoside phosphorylase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2L3Z2 | InterPro | ||||||||||
| UniProtKB:A0A8M9PQQ2 | InterPro | 455 | |||||||||
| UniProtKB:A0A8M3B8W2 | InterPro | 455 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available