Gene
rfx7a
- ID
- ZDB-GENE-100309-3
- Name
- regulatory factor X7a
- Symbol
- rfx7a Nomenclature History
- Previous Names
-
- rfx7
- fc20c08
- wu:fc20c08
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human RFX7 (regulatory factor X7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 71 with behavioral abnormalities | Alliance | Intellectual developmental disorder, autosomal dominant 71, with behavioral abnormalities | 620330 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | DNA-binding RFX-type winged-helix domain | RFX-like DNA-binding protein | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:E7F1P9
|
1509 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-171F19 | ZFIN Curated Data | |
| Encodes | EST | fc20c08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_683773 (1) | 7903 nt | ||
| Genomic | GenBank:CU075695 (1) | 96071 nt | ||
| Polypeptide | UniProtKB:E7F1P9 (1) | 1509 aa |
- Comparative Orthology
- Alliance
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Soyer, J., Flasse, L., Raffelsberger, W., Beucher, A., Orvain, C., Peers, B., Ravassard, P., Vermot, J., Voz, M.L., Mellitzer, G., and Gradwohl, G. (2010) Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (Cambridge, England). 137(2):203-212
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