Gene

vav2

ID
ZDB-GENE-091204-420
Name
vav 2 guanine nucleotide exchange factor
Symbol
vav2 Nomenclature History
Previous Names
  • si:dkeyp-116h7.3
  • wan
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have guanyl-nucleotide exchange factor activity and metal ion binding activity. Predicted to be involved in intracellular signal transduction. Predicted to localize to integral component of membrane. Is expressed in heart. Orthologous to human VAV2 (vav guanine nucleotide exchange factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With vav2 Human Ortholog
No data available
Associated With vav2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR000980 SH2 domain
Domain IPR001452 SH3 domain
Domain IPR001715 Calponin homology domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR022613 Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain
Domain IPR035732 VAV2 protein, second SH3 domain
Domain IPR035880 VAV2, SH2 domain
Domain IPR037832 Vav, PH domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length Calmodulin-regulated spectrin-associated protein-like, Calponin-homology domain Calponin homology domain CH domain superfamily Dbl homology (DH) domain Dbl homology (DH) domain superfamily Guanine-nucleotide dissociation stimulator, CDC24, conserved site PH-like domain superfamily Pleckstrin homology domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain SH2 domain SH2 domain superfamily SH3 domain SH3-like domain superfamily VAV2 protein, second SH3 domain VAV2, SH2 domain Vav, PH domain
UniProtKB:A0A8M9PR05 890
UniProtKB:A0A8M3ALG5 879
UniProtKB:A0A8M3AM66 870
UniProtKB:A0A8M9P3P6 886
UniProtKB:A0A8M9PPX7 819
UniProtKB:A0A8M9PUI9 891
UniProtKB:A0A8M6YV87 880
UniProtKB:A0A8M3ATW1 841
UniProtKB:A0A286Y8W8 875
UniProtKB:A0A8M9PIU4 862
UniProtKB:A0A8M3AWV3 869
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA vav2-201 (1) Ensembl 3,826 nt
mRNA vav2-202 (1) Ensembl 6,219 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations