Gene
tmem163b
- ID
- ZDB-GENE-091204-410
- Name
- transmembrane protein 163b
- Symbol
- tmem163b Nomenclature History
- Previous Names
-
- si:ch73-125n14.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Acts upstream of or within myelination and oligodendrocyte development. Predicted to be located in bounding membrane of organelle; plasma membrane; and synapse. Predicted to be active in synaptic vesicle membrane. Is expressed in brain; central nervous system; spinal cord; and tail bud. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yan et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 25 | Alliance | Leukodystrophy, hypomyelinating, 25 | 620243 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cation efflux protein | Cation efflux transmembrane domain superfamily | Transmembrane protein 163 |
|---|---|---|---|---|
|
UniProtKB:A0A0R4IQD0
|
283 | |||
|
UniProtKB:F2Z4R5
|
284 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tmem163b-201
(1)
|
Ensembl | 891 nt | ||
| mRNA |
tmem163b-202
(1)
|
Ensembl | 1,328 nt | ||
| mRNA |
tmem163b-203
(1)
|
Ensembl | 1,747 nt |
Interactions and Pathways
No data available
Plasmids
No data available