Gene
cpa6
- ID
- ZDB-GENE-091204-331
- Name
- carboxypeptidase A6
- Symbol
- cpa6 Nomenclature History
- Previous Names
-
- si:dkey-78n18.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Enables carboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in several structures, including head; pectoral fin; pectoral fin bud; segmental plate; and tail bud. Human ortholog(s) of this gene implicated in familial febrile seizures 11 and familial temporal lobe epilepsy 5. Orthologous to human CPA6 (carboxypeptidase A6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lopes et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-cpa6 | N/A | (2) |
| MO2-cpa6 | N/A | Lyons et al., 2010 |
| MO3-cpa6 | N/A | Lopes et al., 2016 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial febrile seizures 11 | Alliance | Febrile seizures, familial, 11 | 614418 |
| familial temporal lobe epilepsy 5 | Alliance | Epilepsy, familial temporal lobe, 5 | 614417 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Carboxypeptidase, activation peptide | Metallocarboxypeptidase-like, propeptide | Peptidase M14, carboxypeptidase A |
|---|---|---|---|---|
|
UniProtKB:A0A8M3AW04
|
377 | |||
|
UniProtKB:E7F2H8
|
442 | |||
|
UniProtKB:A0A8M9PUE3
|
189 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-4M13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-78N18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021470305 (1) | 2126 nt | ||
| Genomic | GenBank:CU914550 (1) | 176678 nt | ||
| Polypeptide | UniProtKB:E7F2H8 (1) | 442 aa |
- Akula, S., Hellman, L., Avilés, F.X., Wernersson, S. (2021) Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Developmental and comparative immunology. 127:104273
- Griffin, A., Carpenter, C., Liu, J., Paterno, R., Grone, B., Hamling, K., Moog, M., Dinday, M.T., Figueroa, F., Anvar, M., Ononuju, C., Qu, T., Baraban, S.C. (2021) Phenotypic analysis of catastrophic childhood epilepsy genes. Communications biology. 4:680
- Lopes, M.W., Sapio, M.R., Leal, R.B., Fricker, L.D. (2016) Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. PLoS One. 11:e0152905
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lyons, P.J., Ma, L.H., Baker, R., and Fricker, L.D. (2010) Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. PLoS One. 5(9):e12967
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