Gene

phldb2a

ID

ZDB-GENE-091118-9

Name

pleckstrin homology-like domain, family B, member 2a

Symbol

phldb2a Nomenclature History

Previous Names

si:ch211-244c8.3

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to be involved in regulation of microtubule cytoskeleton organization. Predicted to be active in basal cortex. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa16842	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24883	Allele with one point mutation	Unknown	Splice Site	ENU

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Sequence Targeting Reagents

No data available

Human Disease

Associated With phldb2a Human Ortholog

No data available

Associated With phldb2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR037810	PHLDB1/2/3, PH domain
Family	IPR052212	Pleckstrin homology-like domain-containing protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR027267	AH/BAR domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BK25	InterPro	1079
UniProtKB:A0A8M9QL84	InterPro	1088
UniProtKB:A0A8M9QH75	InterPro	1078
UniProtKB:A0A8M2BJX9	InterPro	1036

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 10

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	phldb2a-201 (1) Ensembl	Ensembl	2,572 nt	Select Tool ZFIN BLAST
mRNA	phldb2a-202 (1) Ensembl	Ensembl	3,593 nt	Select Tool ZFIN BLAST
mRNA	phldb2a-203 (1) Ensembl	Ensembl	171 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-244C8	CR376845	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005172737 (1)	3979 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR376845 (1)	166564 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M9QL84 (1)	1088 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	PHLDB2	3	Ensembl:ENSG00000144824 Gene:90102 HGNC:29573 OMIM:610298	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Phldb2	16	Ensembl:ENSMUSG00000033149 Gene:208177 MGI:2444981	Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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