Gene
rasgrp2
- ID
- ZDB-GENE-091118-124
- Name
- RAS guanyl releasing protein 2 (calcium and DAG-regulated)
- Symbol
- rasgrp2 Nomenclature History
- Previous Names
-
- si:ch211-247j24.2
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| platelet-type bleeding disorder 18 | Alliance | ?Bleeding disorder, platelet-type, 18 | 615888 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000651 | Ras-like guanine nucleotide exchange factor, N-terminal |
| Domain | IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Family | IPR008937 | Ras-like guanine nucleotide exchange factor |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR023578 | Ras guanine nucleotide exchange factor domain superfamily |
| Homologous_superfamily | IPR036964 | Ras guanine-nucleotide exchange factor, catalytic domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras guanine-nucleotide exchange factor, catalytic domain superfamily | Ras guanine nucleotide exchange factor domain superfamily | Ras guanine-nucleotide exchange factors catalytic domain | Ras-like guanine nucleotide exchange factor | Ras-like guanine nucleotide exchange factor, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TAP0
|
592 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rasgrp2-201
(1)
|
Ensembl | 1,740 nt | ||
| mRNA |
rasgrp2-202
(1)
|
Ensembl | 1,642 nt |
Interactions and Pathways
No data available
Plasmids
No data available